Efficient cytosolic delivery of siRNA using HDL-mimicking nanoparticles.
نویسندگان
چکیده
and encapsulation into lipid nanoparticles. [ 7 ] Therapeutic application of RNA interference (RNAi) requires delivery of siRNAs into the cytoplasm of targeted cells and tissues, where they are recognized and associated with RNA-induced silencing complex (RISC) to perform their function. [ 8 ] This rate-limiting delivery step has been dealt with by several approaches, such as co-encapsulation of fusogenic lipid [ 9 ] or fusogenic peptide, [ 10 ] liposomal bubbles and ultrasound, [ 11 ]
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عنوان ژورنال:
- Small
دوره 7 5 شماره
صفحات -
تاریخ انتشار 2011